The lion is come up from his thicket, and the destroyer of the Gentiles is on his way; he is gone forth from his place to make thy land desolate; and thy cities shall be laid waste, without an inhabitant. The lion is come up - Nebuchadnezzar, king of Babylon. "The king (Nebuchadnezzar) is come up from his tower." - Targum.
The destroyer of the Gentiles - Of the nations: of all the people who resisted his authority. He destroyed them all.